Most patients I see have been through multiple antibiotic courses and topical retinoids with partial or temporary results — because the treatment never addressed why the skin was inflamed in the first place. Beautiful skin is a reflection of internal health. Get the biology right and the skin follows.
The pattern I look for is almost always upstream: androgens running high relative to estrogen or progesterone, a gut microbiome that's dysbiotic, blood sugar spiking from a high-glycemic diet, or a liver that's struggling to clear metabolized hormones. Once that foundation is solid, targeted aesthetic treatments — including platelet-rich plasma (PRP) facials — can address what's left on the surface.