Most patients I see have been through multiple antibiotic courses and topical retinoids with partial or temporary results, because the treatment never addressed why the skin was inflamed in the first place. Beautiful skin is a reflection of internal health. Get the biology right and the skin follows.
The pattern is almost always upstream: androgens running high relative to estrogen or progesterone, a dysbiotic gut, blood sugar spiking from a high-glycemic diet, or a liver struggling to clear metabolized hormones. Once that foundation is solid, targeted aesthetic treatments, including PRP facials, can address what's left on the surface.