Dr. Rigobert Kefferputz

Patient Library / Mental Health / Depression

Depression

Depression is not simply a serotonin deficiency — and understanding the full picture changes the treatment entirely.

Depression affects 1 in 5 people at some point in their lives, yet the majority are treated with a single therapeutic approach — antidepressants — without any investigation into the physiological factors that drive or perpetuate it. Neuroinflammation, thyroid dysfunction, nutrient deficiencies, and gut dysbiosis each cause or worsen depression through distinct mechanisms that medication alone cannot address.

Inflammation Is a Driver

A significant proportion of depressed patients have elevated inflammatory markers. Neuroinflammation impairs neurotransmitter production and synaptic function — addressing the inflammatory source produces antidepressant effects that medication can't replicate.

Exercise Is Evidence-Based

Regular aerobic exercise produces antidepressant effects comparable to medication in multiple meta-analyses — through BDNF upregulation, HPA axis modulation, and anti-inflammatory mechanisms. This is not optional advice; it's a primary treatment.

Thyroid & Nutrients First

Subclinical hypothyroidism, vitamin D deficiency, B12, omega-3s, and zinc each directly affect mood and neurotransmitter function. Finding and treating these is often more impactful than adding another antidepressant.

What You Need to Know

Frequently Asked Questions

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How I Treat This

These are the services I most commonly draw on when working with depression.

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